Identification of antiviral compounds against equid herpesvirus-1 using RTCA screening
Equid alpha-herpesviruses (EHV) are responsible for different diseases in equine population, causing respiratory diseases, abortions and nervous disorders. In this webinar, scientists from LABEO Frank Duncombe show how xCELLigence Real-Time Cell Analysis (RTCA) technology can be used to monitor the cytopathic effects induced by EHV-1 on equine dermal cells, and established the efficacy of this method to evaluate the antiviral effects of the drugs aciclovir and ganciclovir. Among the 2891 compounds screened, 22 molecules have been found to be effective in vitro against EHV-1.
Watch the webinar on demand to:
- Understand how real time cell analysis can be used to monitor viral cytophatic effects induced by equid alpha-herpesviruses
- Learn how to develop a high throughput screening method for evaluating antiviral potency of small molecules
- Learn about synergistic interactions between valganciclovir and decitabine through in vitro antiviral assay as determined by impedance measurement and qPCR assays.