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Agilent Vaya handheld Raman spectrometer for raw material ID

Agilent Vaya handheld Raman spectrometer

Streamline and speed up your warehouse receipt process while cutting costs

The Vaya handheld Raman spectrometer is a groundbreaking innovation for testing incoming raw materials. Using spatially offset Raman spectroscopy (SORS) technology, Vaya lets you examine the contents of transparent and opaque containers⁠—without opening or moving them to a sampling booth. The potential impact on your quality control is staggering.

What materials work well with Raman spectroscopy? Learn more

Blue drum

Glycerin in blue drum

Paper sack

Mannitol in paper sack

IBC

Sucralose in IBC

FIBC

Sorbitol in FIBC

White bucket

Citric acid in white bucket

Amber bottle

Polysorbate in amber bottle

Use our calculator tool and see for yourself

Select your current material identification method and enter your typical batch quantities and the number of containers per batch. Based on your input, the process flow chart will automatically update to show the time expenditure differences between methods.

What materials work well with Raman?

Raman spectroscopy is based on the ability of the excitation source to induce a change in its electric dipole with respect to the vibrational and rotational state of the analyte. More simply, and as opposed to infrared spectroscopy where the presence of a simple dipole moment is required, the Raman relaxation phenomenon is based on the ability of the excitation source to induce a dipole within the analyte. The presence of covalent bonds is usually required for a Raman signal to be observed. Following the rules of mutual exclusion with infrared spectroscopy, transitions like C=C, C-C, or C-H⁠—as opposed to transitions like C-O or O-H⁠—will typically be intense in Raman spectroscopy. Rotational and vibrational transitions that are often large in Raman spectroscopy are typically weak in infrared spectroscopy (and vice versa).

What works well?

What does not work?

Related application notes

Select technique

  • Handheld Raman
  • NIR
  • FTIR

Agilent Vaya process

Quarantine illustration

Move to quarantine

All arriving containers are moved to quarantine and a cursory inspection is performed.

ID testing in quarantine illustration

ID testing in quarantine

Vaya identifies raw materials through secondary containers (opaque).

3.5 person days
Production stock illustration

Move to production stock

After approval of analytical tests, raw materials are mixed with production stock.

Other process

Move to sampling booth illustration

Move to sampling booth

A statistical sampling of the raw material containers to be tested are transferred to a sampling booth.

3.8 person days
ID testing with Raman illustration ID testing for NIR illustration ID testing for FTIR illustration

ID testing in sample booth

After opening the secondary (opaque) container, handheld Raman is performed through primary (transparent) containers.

After opening the secondary (opaque) container and the primary (transparent) container, the raw material is directly probed for NIR analysis.

After opening the secondary (opaque) container and the primary (transparent) container, samples are collected and taken to a QC lab for FTIR analysis.

13.6 person days
Back to quarantine illustration

Back to quarantine

Once ID testing is performed, containers are resealed and transferred back to quarantine and the sampling booth is cleaned.

18.8 person days

What does this mean for your operation?

0 person days
saved per year

Agilent Vaya can significantly decrease labor costs by reducing the total time of materials ID.

90% faster with
Agilent Vaya

Bypassing the sampling booth⁠—and decreasing the need for container handling and moving⁠—shortens your processing time.

Assumed 100% ID as opposed to statistical sampling.

Schedule your demo today

From clear glass vials to brown paper sacks, Vaya offers best-in-class identification testing for the fastest possible release to manufacturing. For an up-close look at this next evolution of handheld Raman technology, contact us to schedule your demo.

Contact us now

Learn more about increasing throughput without increasing costs

Video thumbnail

Discover the future of raw material verification

With a simple pass/fail result, Wi-Fi connectivity, and no need to open containers, Vaya boosts efficiency and confidence in your material testing. In this video, we’ll show you how intuitive menus and an onboard barcode scanner make sample identification a breeze.

Video thumbnail

A faster, easier way to validate incoming raw materials

This video demonstrates the speed and flexibility of the Vaya Raman system when compared to traditional raw material identification and verification. You’ll also learn how Vaya makes compliance simple, so you can increase your reach, not your cost.

Gain expert insights into raw material quality control

eBook cover

Raw material identification eBook

Take a deeper dive into through-container verification of pharmaceutical raw materials with Agilent Vaya. In this eBook, you’ll explore the principles behind SORS and how this technology can be applied to identifying raw materials inside plastic containers and paper sacks.

Request eBook
Agilent Vaya handheld Raman spectrometer

Discover how raw material ID testing should be

In this webinar, an Agilent Raman expert explores how SORS addresses common raw material challenges, including discrimination and hard-to-scan materials. You’ll also learn how Raman spectroscopy supports your green initiatives by reducing the need for consumables.

View webinar
ACT label

A sustainable choice for your lab

The ability of Vaya to identify raw materials through transparent and opaque containers reduces time and waste. What’s more, Vaya requires minimal energy use, downtime, and consumables.

Agilent has also partnered with My Green Lab to have the Vaya Raman system independently audited for their Accountability, Consistency, and Transparency (ACT) label.

Learn more

More resources for raw material identification

White paper: Identifying raw materials through containers

Pharmaceutical manufacturers are under increasing pressure to achieve First Time Quality (FTA) while reducing costs. This white paper discusses how deploying a Vaya system simplifies and accelerates the verification of raw materials at receipt.

Download
Agilent Vaya handheld Raman spectrometer

Application note: Verification of common stearates without complex chemometrics

This study shows that the Agilent Vaya handheld Raman spectrometer can identify metal stearates in their original packaging without the need for chemometric software packages. Vaya enables the selective verification of stearates using a two-criteria decision algorithm combined with the “Analogous Sample” software feature.

Download
Agilent Vaya handheld Raman spectrometer

Application note: Opaque container analysis

Verifying raw materials directly through plastic barrels minimizes the need for specialized personnel or controlled sampling environments. This study demonstrates the through-opaque-container analysis capability of Agilent Vaya by measuring common excipients and active ingredients within blue barrels.

Download
Agilent Vaya handheld Raman spectrometer

Application note: Identifying mRNA lipid nanoparticle components

Lipid nanoparticles (LNPs) are used as drug delivery systems for effective on-target payload delivery. This paper explores the implementation of the Vaya system for chemical ID verification and testing of mRNA LNP components through transparent glass and white opaque containers.

Download
Agilent Vaya handheld Raman spectrometer

Application note: Polysorbates identification through amber bottles

Polysorbates are susceptible to degradation through hydrolysis or auto-oxidation when their storage bottles are opened. In this study, Agilent Vaya was used to identify and differentiate PS 20 and PS 80 through amber glass.

Download
Agilent Vaya handheld Raman spectrometer

Agilent Community Vaya user group

The Agilent Community is an online resource for helping each other succeed. It’s the place to seek your colleagues’ help with applications, instruments, and more⁠—and to find in-depth content about topics relevant to your raw material analysis.

Join now
Agilent Vaya handheld Raman spectrometer

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