Transform Your Pharmaceutical End Product Testing

Agilent TRS100 Raman quantitative pharmaceutical analysis system

Placing capsules on a TRS100 tray

Are you spending days testing drug batches for content uniformity?

Eliminate sample preparation and reduce QC testing by days—or weeks—with transmission Raman spectroscopy (TRS).

TRS is ideal for quantitative measurements of oral solid dose forms, such as tablets and capsules. The technique complements HPLC, UV-Vis, and other traditional analytical techniques for content uniformity (CU) testing, and offers these advantages:

  • No sample preparation or solvents required
  • Nondestructive and takes seconds per measurement
  • Ensures that the whole sample stays intact and gathers information about active ingredients within the bulk of the sample
hands holding pack of different tablet blisters

Improve analytical workflows with TRS: On-demand webinar

Anders Sparén, associate principal scientist at AstraZeneca, talks about how TRS can be used to improve analytical workflows and operational efficiencies. In this webinar, you will:

  • Explore different approaches for interpreting and evaluating spectral data.
  • Learn how to apply the benefits of TRS toward an enhanced control strategy.
  • Find out how rapid, nondestructive technology can benefit your lab.
Anders Sparén

Extended Uniformity of Dosage Unit Testing on Pharmaceutical Tablets

Anders Sparén
Associate principal scientist
AstraZeneca

infographic

Discover how TRS can augment your QC workflow

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Concerned about compliance? Don’t be.

The Agilent TRS100 has features that facilitate working in compliant environments. It is ideal for labs that must comply with US FDA 21 CFR Part 11, as well as USP and EP chapters for Raman spectroscopy.

Pharmaceutical manufacturing facilities have also found that switching from standard methods to TRS has:

  • Reduced release testing for an 8-batch campaign from 28 hours to 2 hours
  • Saved $160,000 over one year with over 2,000 batches released
  • Enabled significant testing scale-up without a corresponding increase in personnel or instrument resources
  • Allowed testing to be moved into the manufacturing area—increasing efficiency by freeing the QC lab for more specialized tasks
lab technician working with TRS100 instrument in a lab
Agilent TRS100 ACT label

Make a smart, sustainable choice

The Agilent TRS100 has been recognized by the independent third party My Green Lab for its sustainable attributes and has been assigned an accountability, consistency, and transparency (ACT) label based on its environmental impact.

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TRS application notes

gel capsules

Quantification and Identity Testing of Soft Gel Capsules Using TRS

TRS enables an efficient, cost-effective, and sustainable workflow for QC testing of soft gel capsules—with no sample preparation needed.

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warfarin tablets

Quantitative Analysis of Warfarin Tablets Containing Salt-Form Impurities Using TRS

Here, TRS enables the quantification of Warfarin in whole intact pharmaceutical tablets with a 20-second measurement time and no sample preparation.

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multicolored capsules

Quantification of Tablets Containing Multiple APIs Using TRS

This example, based on a common cold and flu product, demonstrates the quantification of five components with a nine-second measurement time.

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The fundamentals of TRS

Raman spectroscopy, a vibrational spectroscopic technique, provides a chemical fingerprint of the compounds being analyzed. The spectra produced have sharp, distinctive peaks that correspond to molecular vibrations of the chemical functional groups.

TRS is a measurement that scatters light through a material, and is well suited for pharmaceutical tablets and capsules. The laser is on the opposite side of the sample to the detector, resulting in the Raman signal being collected from the bulk of the material. In pharmaceutical products, each ingredient can have many Raman peaks that combine in number and intensity to provide the spectrum.

red light scattering through a pharmaceutical tablet

For a closer look at TRS technology, watch our educational video series

Part 1: What is TRS and how does it work?

Traditional analysis methods can be time- and resource-intensive, and require highly skilled operators. Discover how TRS offers a simpler, nondestructive alternative for performing routine QC tests on solid pharmaceutical products.

Watch now

Part 2: Benefits of TRS over SOP

In pharmaceutical production, batch-release and quality-control testing for dosage uniformity are essential. Learn why TRS is built for rapid, routine testing of solid dosage formats—with benefits that include speed, sustainability, sensitivity, and cost.

Watch now

Part 3: Practical applications

Watch as an Agilent expert shows you how TRS can help relieve the test burden within your analytical laboratory. We’ll also discuss the features and benefits of TRS technology, highlighted with customer case studies.

Watch now

How much could your lab save with TRS?

Adding Transmission Raman spectroscopy as a complimentary content uniformity (CU) analytical method could make a big difference in your bottom line.

To see how your savings can add up, input the key variables of your existing CU analytical workflows into this quick calculator tool.

Input your variables Input  
batches
hours
mL
minutes
Compare the results Traditional analysis TRS
Cost per batch 869 $55
Total workflow time 6.5 hrs 1 hr
Total solvent used 8 0 L
Cost per sample 87 $5

Estimated annual cost savings: 203,488 per year

How does the Agilent TRS100 make these savings possible?

TRS provides a fast, nondestructive bulk analysis of tablets and capsules. This regulatory-approved technique negates the need for sample preparation, saving you time, solvents, and consumables.

Avoid sample preparation

Save 750 operator hours per year that could be used elsewhere.

5,000 saved per year.

Analyze without solvents

Save 1,900 L of solvent per year by eliminating sample preparation, clean up, and disposal.

61,000 saved per year.

Speed up CU testing

17 times faster than traditional analysis.

333 hours saved per year.

Savings increase when you implement multiple analytical methods

When multiple analytical methods are deployed, your cost savings and return on investment increase dramatically.

The calculations shown on this page are illustrative estimations using industry standard values verified with existing system users. To work through a customized calculation with your local Transmission Raman product specialist, contact us.

Request a custom calculation
Guide to TRS100 Analytical Method Development

Developing TRS methods? Read our expert guide.

This step-by-step guide will help you develop quantitative TRS methods that meet the regulatory standards required for release testing.

Download now

Hear how pharmaceutical labs are advancing their research with TRS

What are the advantages of Raman spectroscopy? How does Raman spectroscopy compare with other traditional techniques? What technologies should your lab focus on in the face of ever-tightening budgets?

You’ll learn the answers to these and other questions in our new webinar, featuring a panel of thought leaders from the pharmaceutical industry.

  • Understand the rationale and business case of TRS, as well as the key steps for method development success.
  • Hear how companies are overcoming the lack of education about TRS.
  • Explore how regulatory concerns apply to innovator pharmaceutical corporations versus manufacturers of generics.
  • Listen to stories about hands-on implementation of TRS in pharmaceutical manufacturing, and the challenges faced during this process.
webinar title screen

Webinar:
Advance with Transmission Raman

Access webinar now

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