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Screening Demystified: Practical Guidelines for Getting It Right with High-Resolution

Join us for an insightful two-part webinar series exploring high-resolution LC/MS screening and unlocking instrument capabilities.

In these sessions, we’ll address common misconceptions about HRMS screening and provide practical guidance to help you achieve confident, efficient screening in complex analytical workflows. Discover strategies, best practices, and expert insights that will empower you to streamline your processes and maximize the value of your instrumentation.

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Screening Demystified: Practical Guidelines for Getting It Right with High-Resolution Part 1: All About Screening

Screening with LC/QTOF can bring a new dimension to many labs’ capabilities, massively expanding the scope of their analyses. However, although QTOF screening is a powerful tool, its complexity should not be underestimated; high resolution accurate mass spectrometry (HRAMS) data is inherently complex and careful experimental design and deployment of the correct hardware and software tools are vital to avoid potential pitfalls like false positives or negatives, poor reproducibility and possibly even regulatory or reputational risks for the lab itself. This session will challenge some of the misconceptions surrounding HRAMS screening and will introduce general concepts, such as targeted, suspect and non-targeted screening workflows.

Who should attend?

Scientists already using HRMS who need insights about their methods, results, or workflows and scientists considering moving to HRMS screening and looking for clarity on what it can and can’t deliver.

Speakers:

Jonathan Spencer
Christian Hegmanns

Screening Demystified: Practical Guidelines for Getting It Right with High-Resolution Part 2: How to Set-Up for Success

In this session we demystify instrument capabilities, highlighting key performance metrics and practical considerations for reliable results. Complementing this, we present personal experiences when assessing and improving screening workflows, emphasizing that overly selective sample preparation can bias screening outcomes. The guidelines include technical specifications, essential software tools, operator competencies, and validation strategies, enabling laboratories to benchmark their processes. Together, these insights provide a roadmap for achieving confident, streamlined screening in complex analytical environments.

Who should attend?

Scientists already using HRMS who need insights about their methods, results, or workflows and scientists considering moving to HRMS screening and looking for clarity on what it can and can’t deliver.

Speakers:

Shaun Reeksting
Dr Christian Klein
Dr Susanne Soelter

Speakers:

Jonathan Spencer

Jonathan Spencer

Field Application Specialist LC/MS
Agilent Technologies

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Christian Hegmanns

Christian Hegmanns

Application Specialist LC/MS
Agilent Technologies, Inc.

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Shaun Reeksting

Shaun Reeksting

Field Application Specialist LC/MS,
Agilent Technologies

Learn More
Dr Christian Klein

Dr Christian Klein

Biopharma Application Specialist,
Agilent Technologies

Learn More
Dr Susanne Soelter

Dr Susanne Soelter

Field Application Specialist LC/MS,
Agilent Technologies

Learn More

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Jonathan Spencer

Jonny studied BSc Natural Sciences at the University of Nottingham, where he divided his studies between chemistry and biochemistry. He went on to study MSc Forensic Science at Sheffield Hallam University. Following graduation, he spent 2 years as a Confirmatory Analyst in an anti-doping and forensic toxicology lab, before joining Agilent as an LC-MS Applications Scientist. At Agilent, he focuses on small molecule applications using LC-TQ and LC-QTOF in fields like food, forensic and environmental analysis.

Christian Hegmanns

Christian Hegmanns is a state-certified food chemist and works at Agilent as an LC/MS application specialist. With over 10 years of experience in the field of instrumental analysis, Christian develops customer-oriented solutions for a variety of applications with a focus on food analysis.

Shaun Reeksting

Shaun has a passion for bridging the gap between complex science and practical solutions. With over a decade of experience in mass
spectrometry—from hands-on method development in academic and commercial labs to supporting cutting-edge analytical workflows, he thrives on helping customers discover the fascinating world of multi-molecule analyses and unlocking insights from their data.

Dr Christian Klein

With an education in Chemistry, Chris Klein received his PhD in 2005 at the Max-Planck-Institute for Biochemistry in Martinsried, Germany. After a PostDoc and 3 years as demo chemist and product specialist with Bruker Daltonics in California, Chris joint Agilent Technologies’ LC/Q-TOF R&D team in 2010 and took in 2018 the role as LC/Q-TOF and IM-QTOF Product Manager. In 2025 he returned to Germany as Biopharma Application Specialist in Waldbronn.

Dr Susanne Soelter

Susanne Soelter started her career as a product specialist for LC/MS 2004. She has remained loyal to LC/MS since then. In her current position as a Field Application Specialist, she develops new methods in the Agilent laboratory in Waldbronn and supports customers on site.

Susanne studied chemistry in Hamburg and received a doctorate degree in organic chemistry from the University of Hamburg.