Legacy NGS Product Discontinuation

Timeline Affected products New solutions FAQs Contact us

Plan ahead: Product discontinuation timeline

Plan and prepare for the transition of your legacy Agilent NGS products to the next-generation solutions.

Affected SureSelect products

SureSelect QXT

Part Number	Product Name
G9683A	SureSelect QXT Reagent Kit, ILMN 16 rxn
G9683B	SureSelect QXT Reagent Kit, ILMN 96 rxn
G9684A	SureSelect QXT Library Prep Kit, 16 rxn
G9684B	SureSelect QXT Library Prep Kit, 96 rxn
5500-0118	SureSelect QXT Dual Index Kit, ILM

SureSelect XT

Part Number	Product Name
G9611A	SureSelect XT Reagent kit, HSQ, 16 rxn
G9611B	SureSelect XT Reagent kit, HSQ, 96 rxn
G9611C	SureSelect XT Reagent kit, HSQ, 480 rxn
G9612A	SureSelect XT Reagent kit, MSQ, 16 rxn
G9612B	SureSelect XT Reagent kit, MSQ, 96 rxn
G9641B	SureSelect XT Reagent kit, HSQ, 96 rxn, automation
G9641C	SureSelect XT Reagent kit, HSQ, 480 rxn, automation
G9642B	SureSelect XT Reagent kit, MSQ, 96 rxn, automation
G9642C	SureSelect XT Reagent kit, MSQ, 480 rxn, automation
5190-7951	SureSelect XT Index Set ILM, 96 rxn

SureSelect XT HS

Part Number	Product Name
5190-9876	SureSelect XT HS Index Primers 1-32 for ILM, 96 rxn
5500-0141	SureSelect XT HS Index Primers 1-16 ILM
5500-0142	SureSelect XT HS Index Primers 17-32 ILM
Reagent Kit Part Number	Product Name
G9702A	SureSelect XT HS Reagent Kit 1-16, 16 rxn
G9702B	SureSelect XT HS Reagent Kit 17-32, 16 rxn
G9702C	SureSelect XT HS Reagent Kit 1-32, 96 rxn
G9916B	SureSelect XT HS TE Kit, ILM, 16 Rxn
Reagent Kit w/Panel Part Number	Product Name
G9704A	SureSelect XT HS index 1-16 + 1 - 499 kb panel, 16rxn
G9704B	SureSelect XT HS index 1-16 + 0.5 - 2.9 Mb panel, 16 rxn
G9704C	SureSelect XT HS index 1-16 + 3 - 5.9 Mb panel, 16 rxn
G9704D	SureSelect XT HS index 1-16 + 6 - 11.9 Mb panel, 16 rxn
G9704E	SureSelect XT HS index 1-16 + 12 - 24 Mb panel, 16 rxn
G9705A	SureSelect XT HS index 17-32 + 1 - 499 kb panel, 16 rxn
G9705B	SureSelect XT HS index 17-32 + 0.5 - 2.9 Mb panel, 16 rxn
G9705C	SureSelect XT HS index 17-32 + 3 - 5.9 Mb panel, 16 rxn
G9705D	SureSelect XT HS index 17-32 + 6 - 11.9 Mb panel, 16 rxn
G9705E	SureSelect XT HS index 17-32 + 12 - 24 Mb panel, 16 rxn
G9706A	SureSelect XT HS index 1-32 + 1 - 499 kb panel, 96 rxn
G9706B	SureSelect XT HS index 1-32 + 0.5 - 2.9 Mb panel, 96 rxn
G9706C	SureSelect XT HS index 1-32 + 3 - 5.9 Mb panel, 96 rxn
G9706D	SureSelect XT HS index 1-32 + 6 - 11.9 Mb panel, 96 rxn
G9704G	SureSelect XT HS index 1-16 + ClearSeq comprehensive cancer panel, 16 rxn
G9705G	SureSelect XT HS index 17-32 + ClearSeq comprehensive cancer panel, 16 rxn
G9706G	SureSelect XT HS index 1-32 + ClearSeq comprehensive cancer panel, 96 rxn
G9704H	SureSelect XT HS index 1-16 + Clinical Research exome V2 panel, 16 rxn
G9705H	SureSelect XT HS index 17-32 + Clinical Research exome V2 panel, 16 rxn
G9706H	SureSelect XT HS index 1-32 + Clinical Research exome V2 panel, 96 rxn
G9704K	SureSelect XT HS index 1-16 + Human All Exon V6 panel, 16 rxn
G9705K	SureSelect XT HS index 17-32 + Human All Exon V6 panel, 16 rxn
G9706K	SureSelect XT HS index 1-32 + Human All Exon V6 panel, 96 rxn
G9704M	SureSelect XT HS index 1-16 + Human All Exon V6 + UTR panel, 16 rxn
G9705M	SureSelect XT HS index 17-32 + Human All Exon V6 +UTR panel, 16 rxn
G9704N	SureSelect XT HS index 1-16 + Human All Exon V7 panel, 16 rxn
G9705N	SureSelect XT HS index 17-32 + Human All Exon V7 panel, 16 rxn
G9706N	SureSelect XT HS index 1-32 + Human All Exon V7 panel, 96 rxn
G9704P	SureSelect XT HS index 1-16 + Human All Exon V7 Plus 1 panel, 16 rxn

SureSelect XT low input

Part Number	Product Name
G9916A	SureSelect XT Low Input Reagent Kit, Low Input Lib Prep Kit, Index 1-96, 96 Rxn
5191-4056	SureSelect XT Low Input Reagent Kit, Dual Index P5 indexed Adaptors 1-96
5190-6444	SureSelect XT Low Input Index Primer 1-96 for ILM
5190-6445	SureSelect XT Low Input Index Primer 97-192 for ILM
G9703A	SureSelect XT Low Input Reagent Kit, indexes 1-96, 96rxn
G9703B	SureSelect XT Low Input Reagent Kit, indexes 97-192, 96rxn
Reagent Kit w/Panel Part Number	Product Name
G9507A	SureSelect XT Low Input Reagent Kit, index 1-96 + 1-499 kb panel, 96 rxn, automation
G9507B	SureSelect XT Low Input Reagent Kit, index 1-96 + 0.5-2.9 Mb panel, 96 rxn, automation
G9507C	SureSelect XT Low Input Reagent Kit, index 1-96 + 3-5.9 Mb panel, 96 rxn, automation
G9507D	SureSelect XT Low Input Reagent Kit, index 1-96 + 6-11.9 Mb panel, 96 rxn, automation
G9507E	SureSelect XT Low Input Reagent Kit, index 1-96 + 12-24 Mb panel, 96 rxn, automation
G9508A	SureSelect XT Low Input Reagent Kit, index 97-192 + 1-499 kb panel, 96 rxn, automation
G9508B	SureSelect XT Low Input Reagent Kit, index 97-192 + 0.5-2.9 Mb panel, 96 rxn, automation
G9508C	SureSelect XT Low Input Reagent Kit, index 97-192 + 3-5.9 Mb panel, 96 rxn, automation
G9707A	SureSelect XT Low Input Reagent Kit, index 1-96 + 1-499 kb panel, 96 rxn
G9707B	SureSelect XT Low Input Reagent Kit, index 1-96 + 0.5-2.9 Mb panel, 96 rxn
G9707C	SureSelect XT Low Input Reagent Kit, index 1-96 + 3-5.9 Mb panel, 96
G9707D	SureSelect XT Low Input Reagent Kit, index 1-96 + 6-11.9 Mb panel, 96 rxn
G9708A	SureSelect XT Low Input Reagent Kit, index 97-192 + 1-499 kb panel, 96 rxn
G9708B	SureSelect XT Low Input Reagent Kit, index 97-192 + 0.5-2.9 Mb panel, 96 rxn
G9708D	SureSelect XT Low Input Reagent Kit, index 97-192 + 6-11.9 Mb panel, 96 rxn
G9707G	SureSelect XT Low Input Reagent Kit, index 1-96 + ClearSeq comprehensive cancer panel, 96 rxn
G9507H	SureSelect XT Low Input Reagent Kit, index 1-96 + Clinical Research exome v2 panel, 96 rxn, automation
G9508H	SureSelect XT Low Input Reagent Kit, index 97-192 + Clinical Research exome v2 panel, 96 rxn, automation
G9707H	SureSelect XT Low Input Reagent Kit, index 1-96 + Clinical Research exome v2 panel, 96 rxn
G9708H	SureSelect XT Low Input Reagent Kit, index 97-192 + Clinical Research exome v2 panel, 96 rxn
G9507K	SureSelect XT Low Input Reagent Kit, index 1-96 + Human All Exon v6 panel, 96 rxn, automation
G9508K	SureSelect XT Low Input Reagent Kit, index 97-192 + Human All Exon v6 panel, 96 rxn, automation
G9707K	SureSelect XT Low Input Reagent Kit, index 1-96 + Human All Exon v6 panel, 96 rxn
G9708K	SureSelect XT Low Input Reagent Kit, index 97-192 + Human All Exon v6 panel, 96 rxn
G9708H	SureSelect XT Low Input Reagent Kit, index 97-192 + Clinical Research exome v2 panel, 96 rxn
G9507M	SureSelect XT Low Input Reagent Kit, index 1-96 + Human All Exon V6 +UTR panel, 96 rxn, automation
G9508M	SureSelect XT Low Input Reagent Kit, index 97-192 + Human All Exon V6 +UTR panel, 96 rxn, automation
G9707M	SureSelect XT Low Input Reagent Kit, index 1-96 + Human All Exon V6 +UTR panel, 96 rxn
G9708M	SureSelect XT Low Input Reagent Kit, index 97-192 + Human All Exon V6 +UTR panel, 96rxn
G9507N	SureSelect XT Low Input Reagent Kit, index 1-96 + Human All Exon V7 panel, 96 rxn, automation
G9508N	SureSelect XT Low Input Reagent Kit, index 97-192 + Human All Exon V7 panel, 96 rxn, automation
G9707N	SureSelect XT Low Input Reagent Kit, index 1-96 + Human All Exon V7 panel, 96 rxn
G9708N	SureSelect XT Low Input Reagent Kit, index 97-192 + Human All Exon V7 panel, 96 rxn

SureSelect XT RNA Direct and SureSelect Strand-specific RNA

Part Number	Product Name
G7564A	SureSelect XT RNA Direct Library Preparation kit, 16rxns
G7564B	SureSelect XT RNA Direct Library Preparation kit, 96rxns
5500-0134	SureSelect RNA Library Prep, 16 Rxn
5500-0135	SureSelect RNA Library Prep, 96 Rxn
G9691A	SureSelect Strand - Specific RNA Library Preparation kit for ILMN, 16 rxns
G9691B	SureSelect Strand - Specific RNA Library Preparation kit for ILMN, 96 rxns

Meet your new, next-generation solutions

Discover advanced alternatives that deliver superior performance.

SureSelect Max

Agilent SureSelect Max reagents are our most advanced DNA, RNA, and mRNA solutions, designed for researchers who demand the highest quality results.

Enhanced sensitivity for low-input samples
Superior uniformity across target regions
Streamlined workflow that saves time
Compatible with existing panels

Explore now

SureSelect XT HS2

Agilent SureSelect XT HS2 reagents provide high-sensitivity enrichment for applications requiring maximum detection capabilities.

Optimized for FFPE samples
Exceptional on-target performance
Reduced hands-on time for increased efficiency
Proven reliability at scale

Explore now

Why should I transition to SureSelect Max?

Maximum Data Confidence. Maximum Sequencing Cost Efficiency.

Why do Complexity and PCR Duplication matter?

High complexity preserves uniqueness which minimizes redundancy and data waste for maximum cost efficiency. Higher complexity can also enhance sensitivity for low frequency variants¹ and more data confidence.
Low PCR duplication rates also maximize cost efficiency by minimizing redundancy. High complexity and low PCR duplication combine to ensure robust performance and more data confidence in pre-capture pooling as sample multiplexing increases².

Why do Uniformity and Base Coverage matter?

High uniformity maximizes cost-efficiency by ensuring every target region is represented with consistent read depth for fewer wasted reads and more actionable data³.
High base coverage pairs with high uniformity for more data confidence, increased sensitivity, and high conviction variant calling⁴.

References

Head SR, Komori HK, LaMere SA, Whisenant T, Van Nieuwerburgh F, Salomon DR, Ordoukhanian P. Library construction for next-generation sequencing: overviews and challenges. Biotechniques. 2014 Feb 1;56(2):61-4, 66, 68, passim. doi: 10.2144/000114133. PMID: 24502796; PMCID: PMC4351865
Sims D, Sudbery I, Ilott NE, Heger A, Ponting CP. Sequencing depth and coverage: key considerations in genomic analyses. Nat Rev Genet. 2014 Feb;15(2):121-32. doi: 10.1038/nrg3642. PMID: 24434847.
Rohland N, Reich D. Cost-effective, high-throughput DNA sequencing libraries for multiplexed target capture. Genome Res. 2012 May;22(5):939-46. doi: 10.1101/gr.128124.111. Epub 2012 Jan 20. PMID: 22267522; PMCID: PMC3337438.
Sims D, Sudbery I, Ilott NE, Heger A, Ponting CP. Sequencing depth and coverage: key considerations in genomic analyses. Nat Rev Genet. 2014 Feb;15(2):121-32. doi: 10.1038/nrg3642. PMID: 24434847.

Need help choosing?

Not sure which product is right for your application? Our team can help you find the perfect match.

Personalized product recommendations
Technical application support
Transition planning assistance
Validation and optimization guidance

Contact us

Frequently Asked Questions

We've compiled answers to the most common questions about this transition

Why are these products being discontinued?

We're evolving our SureSelect portfolio to focus on next-generation chemistry that delivers superior performance. SureSelect Max and XT HS2 represent significant advances in sensitivity, uniformity, and workflow efficiency based on years of customer feedback and innovation.

Will my existing panels work with the new products?

Yes! All existing SureSelect panels remain fully compatible with both SureSelect Max and XT HS2. You won't need to redesign or reorder your custom panels.

How do I determine which replacement product is right for me?

The best product depends on your specific application. SureSelect Max is ideal for most DNA, RNA, and mRNA applications requiring enhanced sensitivity and uniformity. XT HS2 is optimized for high-sensitivity applications, particularly with FFPE samples. Our technical support team can provide personalized recommendations based on your workflow.

What if I need to order after the last order date?

We recommend planning your inventory needs and placing orders before November 30, 2026. After this date, the products will no longer be available. Contact your sales representative to discuss your anticipated needs and ensure adequate supply.

Will I need to revalidate my workflows?

While the new products deliver improved performance, we recommend validation testing as you would with any workflow change. Our technical team can provide validation support and guidance to help streamline this process. Many customers find the transition straightforward due to protocol similarities.

What support is available during the transition?

We're committed to supporting you throughout this transition. Technical support for current products continues through March 1, 2028. Additionally, our team is available to help with product selection, protocol optimization, and troubleshooting for the new products.

Are there any pricing changes with the new products?

Please contact your sales representative for detailed pricing information. We're committed to providing excellent value with these advanced products.

Where can I find technical documentation for the new products?

Complete technical documentation, protocols, and application notes are available on our website and through your sales representative. We also offer webinars and training sessions to help you get started.

Find everything you need to navigate this transition smoothly

Get detailed answers to your technical questions.

Email Technical support

Connect with your dedicated account manager.

Contact Sales support

Contact us about transitioning to XTHS2 or SureSelect Max

Contact us

For research use only. Not for use in diagnostic procedures.

PR7004-1366