From Identity Confirmation to Aggregate Analysis
Characterize AAVs from Intact Vector down to Single Amino Acid Modifications
Adeno-associated viruses (AAVs) are the main viral vectors for gene therapy and have been successful in treating inherited retinal diseases and spinal muscular atrophy. As AAVs are explored as therapeutic delivery platforms, it is vital to ensure that all the critical quality attributes (CQAs) of the therapeutic product are monitored.
Reversed phase LC/MS for intact proteins and peptide mapping.
Agilent offers technical application notes to support your method development.
Attend our on-demand webinar series discussing BioPharma Purification and Analysis Solutions.
Shop the range of Agilent reversed phase columns for capsid identity.
Ion-exchange chromatography is an invaluable tool for quantifying the ratio of full to empty AAV capsids reproducibly and efficiently.
Analysis of Full/Empty Capsid Ratios in Adeno-Associated Virus 1 and 6 Serotypes Using Biocompatible Liquid Chromatography
Shop the range of Agilent ion-exchange columns for AAV empty/full analysis.
Size exclusion chromatography (SEC) is an effective method for analyzing high-molecular-weight aggregates and related low-molecular-weight degradants.
Resolution of Adeno-Associated Viral Vector Aggregates and Fragments with Agilent Bio SEC-5
Agilent Bio SEC-5 for Analysis of Virus-Like Particles (VLP)
Enables multiple workflows in biopharmaceutical characterization.
Viral-based gene delivery and expression systems provide exceptionally high-efficiency gene delivery to a broad range of hosts.
A single flow path ultra-high performance LC stack that can run any HPLC or UHPLC experiment.
Enables several easy-to-use protein characterization workflows.
RA44742.521724537
LC/MS of Intact Adeno-Associated Virus Capsid Proteins for Rapid Confirmation of Product Identity
Characterization of Viral Vector Particles Using the Agilent 6545XT AdvanceBio LC/Q-TOF
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