Metabolic dysfunction is an early pathogenic event in amyotrophic lateral sclerosis (ALS), which can influence disease progression rates. In this webinar, Dr. Scott Allen will discuss how understanding the effect of the disease on catabolic pathways that influence energy generation will lead to an in-depth awareness of how ALS affects energy supply in the central nervous system. With this information, nutritional supplementation or gene therapy approaches can be used to target the dysfunction and potentially slow down disease progression. Moreover, understanding how astrocytes (a key metabolic support cell to neurons) respond metabolically to pathogenic stress mechanisms, such as mitochondrial dysfunction and hypoxia, will uncover potential future therapeutic targets.

Tune in to learn more about:

• Astrocyte metabolic biology in health and disease
• The metabolic response to hypoxia in astrocytes
• Targeted metabolic supplementation on astrocyte function