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Webinar On Demand:

Multi-modal Assessment of Cardiotoxicity In Vitro Using Human Relevant Cardiomyocytes as part of an Integrated Workflow

Multi-modal Assessment of Cardiotoxicity In Vitro Using Human Relevant Cardiomyocytes as part of an Integrated Workflow

Cardiomyocyte excitation-contraction coupling involves a number of intricately choreographed biochemical, electrophysiological and morphological events culminating in physical beating of cardiomyocytes. It is imperative that frontline in vitro cell based screens are designed in a manner that is comprehensive and able to assess cardiotoxicity from multiple perspectives, including integrated ion channel activity, calcium dynamics, contractility and viability. In this webinar we will discuss how the xCELLigence real-time cell analysis instruments including Cardio, CardioECR, ePacer and eSight can be used in conjunction with human induced pluripotent stem cell derived cardiomyocytes within an integrated workflow to assess compound-mediated cardiotoxicity in the context of :

  • Calcium dynamics
  • Contractility and inotropy
  • Viability and structural integrity

Presenters

Yama A. Abassi, Ph.D.

Head of Business and Assay Development, Cell Analysis, Agilent Technologies

Xiaoyu Zhang, Ph.D.

Sr. Research Scientist, Cell Analysis, Agilent Technologies

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